Equioxx Chewable Tablets for Horses: What to Know

Quick answer

Equioxx (firocoxib) is a prescription COXIB-class NSAID that controls osteoarthritis pain and inflammation in horses for up to 24 hours per dose. It has been tested in more safety studies than any other equine NSAID, making it a strong choice for long-term joint care when your veterinarian recommends it.

How Equioxx differs from traditional horse NSAIDs

Equioxx belongs to the COXIB class, meaning it selectively inhibits COX-2 enzymes responsible for pain and inflammation while sparing COX-1 enzymes that protect the stomach lining and kidneys. Traditional NSAIDs like phenylbutazone or flunixin meglumine block both COX-1 and COX-2, which can increase the risk of gastrointestinal and renal side effects, especially with prolonged use.

This selectivity makes Equioxx a preferred option for horses that need consistent daily anti-inflammatory support, such as those with chronic osteoarthritis. However, it is not suitable for acute colic pain or soft-tissue injuries where a broader-acting NSAID may be more appropriate.

Dosing and administration considerations

Equioxx is available as chewable tablets in multiple strengths, making it easy to adjust the dose based on your horse's weight and pain severity. The typical loading dose is 0.1 mg per kg (0.045 mg per lb) once daily for the first day, followed by a maintenance dose of 0.045 mg per kg (0.02 mg per lb) once daily. Your veterinarian will provide the exact prescription.

Because it is chewable, most horses accept it readily when mixed with a small amount of feed. Avoid giving it on an empty stomach, and never split tablets unless the scored line indicates it is safe to do so. Consistent daily dosing is key to maintaining steady blood levels.

Safety and monitoring

Equioxx has been tested in more horses in safety studies than any other equine NSAID, which gives owners and vets confidence in its long-term use. However, no NSAID is risk-free. Watch for signs of gastrointestinal upset (reduced appetite, loose manure, colic) or changes in drinking and urination that could indicate kidney stress.

Horses with pre-existing kidney disease, liver disease, or a history of gastric ulcers should use Equioxx only under close veterinary supervision. It is also not approved for use in pregnant or lactating mares, or in horses intended for human consumption.

Decision rules for Equioxx

• When to choose Equioxx: Use Equioxx when your horse has confirmed osteoarthritis and needs daily, long-term pain and inflammation control with a lower risk of gastrointestinal side effects compared to traditional NSAIDs. Always start with a veterinary diagnosis and prescription.
• Dosing precision matters: Weigh your horse accurately and follow the loading and maintenance dose schedule provided by your vet. Do not exceed the recommended dose or combine with other NSAIDs. Keep a log of daily doses to avoid accidental double-dosing.
• Monitor for side effects: Watch for decreased appetite, lethargy, diarrhea, or changes in urination. Report any concerns to your veterinarian immediately. Periodic blood work may be recommended for horses on long-term therapy. Schedule a recheck with your vet 2-4 weeks after starting Equioxx.

Product facts

• Equioxx Chewable Tablets for Horses: Equioxx is a non-steroidal, anti-inflammatory drug for the control of pain and inflammation associated with osteoarthritis in horses. Each dose controls pain and inflammation for up to 24 hours. Once-daily dosing simplifies your routine and provides round-the-clock relief, which is especially helpful for horses with chronic joint issues that need consistent management.

  

Is Equioxx right for your horse?

Best for

• Horses with chronic osteoarthritis needing daily NSAID therapy
• Owners who prefer a once-daily chewable tablet that horses accept easily

Not ideal for

• Acute colic or severe soft-tissue injuries where a broader NSAID may be needed
• Horses with known kidney disease, gastric ulcers, or those that are pregnant or lactating